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Cuproptosis is a copper iondependent form of programmed cell death that leads to abnormal oligomerization of lipoylated proteins and dysfunction of iron-sulfur cluster proteins in the mitochondrial tricarboxylic acid (TCA) cycle, thereby triggering intracellular oxidative stress and proteotoxic stress

doi: 10.1038/s41582-022-00749-z, PMID: [DOI] [PubMed] [Google Scholar] Tziortzouda P., Van Den Bosch L., Hirth F

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Once circulating in the bloodstream, these free-form amino acids are readily and efficiently taken up by cells across the entire body, including the highly guarded brain, liver, and skeletal muscle tissue

Glutaconate bound to coenzyme A, glutaconyl-CoA, is an intermediate in lysine metabolism

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