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Patients taking certain medications (e.g., chloramphenicol may reduce the effectiveness of B12 therapy) or with risk factors for B12 deficiency (metformin use, proton pump inhibitors, nitrous oxide exposure, vegan diet) should discuss these with their healthcare provider

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On days 13, plasma dUrd levels were significantly higher than baseline, and this may suggest rapid TS inhibition after dosing

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Whether you need more, less, or a completely different approach depends on factors most doctors never consider