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Clinical observation suggests that doses between 5001000mg daily cause constipation in approximately 2530% of users, with incidence rising to nearly 50% at doses above 1500mg daily

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Using the brain scans of participants before the dose and at intervals in the hour following, the research team was able to observe how well the antioxidant was delivered across the blood brain barrier

[DOI] [PubMed] [Google Scholar] 255.Askari G., Pezeshki A., Safi S., Feizi A., Karami F

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Probable etiologies of vitamin B 12 deficiency in patients without a history of gastrectomy were also suggested