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However, derepression of these can result in high-level expression and an increase in MICs for susceptible -lactams, either as a result of mutation or through induction by particular -lactams ( Penicillins, the majority of cephalosporins, cephamycins, and monobactams are all hydrolyzed by cAmpC when it is expressed constitutively, whereas carbapenems and the fourth-generation cephalosporins are not