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One of its best-characterised roles involves stimulating collagen, elastin, and glycosaminoglycan synthesis within fibroblasts

Therefore, emphasis should be placed on combining energy-restriction with a high protein diet and physical activity, to provide the maximal anabolic stimulus, ensuring weight loss is not associated with loss of muscle mass, or, more importantly, muscle strength [67, 68]

(9) Obesity has also been demonstrated to be protective against osteoporosis due to estrogen production from adipose tissue

Kummer TT, Misgeld T, Sanes JR

This is receptor adaptation, not a results phase

The North America ALS/IGF-I Study Group