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Argollo MC, Allocca M, Furfaro F, Peyrin-Biroulet L, Danese S

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Prompted by report that RXR is important in liver regeneration (Imai et al., 2001), we examined changes in GSH homeostasis in mice with liver specific RXR deletion (Wu et el., 2004)

doi: 10.1016/j.toxicon.2016.10.013 Mohanty, Biswaranjan, Williams, Martin L., Doak, Bradley C., Vazirani, Mansha, Ilyichova, Olga, Wang, Geqing, Bermel, Wolfgang, Simpson, Jamie S., Chalmers, David K., King, Glenn F., Mobli, Mehdi and Scanlon, Martin J

Vitamin A, otherwise known as retinol, has antioxidant properties similar to Vitamin C / Glutathione that helps protect cells against oxidative stress and damage caused by environmental toxins

Recent whole animal genetic studies reviewed here, however, suggest that in many if not all mammalian cells, either the GSH or the Trx pathway alone might be robust at supporting S phase RNR activity in the absence of the other