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However, KEAP1 regulates multiple pathways beyond NRF2 60,82 , and the contributions of NRF2 to lipid homeostasis have been reported to be pleiotropic and context-dependent 83

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Metaboloepigenetic regulation via mitochondria A major component of this mitoepigenetic interplay is metaboloepigenetics, in which metabolic intermediates and cofactors influence chromatin-modifying enzyme and thereby shape gene expression

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