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Management of neuroleptic malignant syndrome requires immediate discontinuation of the offending antipsychotic and aggressive supportive care, including rapid cooling and intravenous fluids to maintain renal perfusion

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GSH-conjugate export carriers (known variably as GS-X pumps or multispecific organic anion transporters) are involved, and this export function is undertaken, in large part, by the ABC transporters MRP1 and MRP2 (Cole and Deeley, 2006