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The Hedgehog (Hh) signaling pathway with three proteins which is involved in activation (Hedgehog (Hh) ligand, Patched (Ptch) and Smoothened (Smo)) is a conserved evolutionary pathway that transmits signals from the cell membrane to the nucleus

5 It may also support collagen and elastin production, improve firmness and texture, and reduce inflammation that drives chronic skin conditions over time

While these mechanistic insights support the biological plausibility of IFs benefits, most data come from animal studies or short-term human trials, raising questions about their generalizability to long-term clinical outcomes

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10.1016/j.ejim.2018.04.014 185