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Our findings open avenues to identify cancer subtypes that hyperprogress in response to ICT by hijacking myeloid-affiliated pathways and thus allows for the development of effective combination therapies by targeting this mechanism of hyperprogression, and also support the emerging strategy of combining epigenetic modulators with ICT to prevent tumor-promoting epigenetic processes in cancers that are resistant to ICT 50 and possibly other therapies

Kowluru RA, Kowluru A, Mishra M, Kumar B (2015) Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy

doi: 10.1186/1744-8069-4-52 40 HoringBKerkemeyerMBchelC

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Ageing, sun exposure, pollution, smoking, stress, lack of sleep, and poor nutrition can slowly drain the bodys natural antioxidants