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2007 Jul 5;448(7149):73 7

YangXMaoZHuangYYanHYanQHongJet al

Creation of transient pores by -synuclein oligomers induce similar effects of uncoupling electron transport from ATP production, resulting in release of free electrons and cytochrome c and concomitant ROS generation

The honest way to hold this fact is in two hands at once: the causal link was not proven, and the episode is nonetheless a real part of why the DAC form never advanced and why the compound class is treated with caution