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In mouse tumor models, the use of anti-PD-1 or anti-PD-L1 (clone 6E11) with anti-VEGFR-2 (DC101) induces synergistic effects to inhibit tumor growth [107,108] Various ongoing clinical studies focus on the combination of anti-PD-1/PD-L1 and anti-VEGF/VEGFR-2 antibodies in lung cancer (NCT02366143), hepatocellular carcinoma (NCT04102098 and NCT03434379), metastatic colorectal cancer (NCT02997228), renal cell carcinoma (NCT024420821), gastric cancer (NCT02572687), carcinoma of urethral epithelium (NCT02443324), biliary tract cancer (NCT02443324), etc

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These effects were dependent on the activation of the mitogen activated protein kinase (MAPK) pathway (154)

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