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Amy Yasko talks about folks with a particular mutation status for COMT & VDR Taq as best needing the below forms of B12:

Weight management research explores compounds that influence energy balance, appetite regulation, and metabolic efficiency

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Turmeric: Curcuminoids and other compounds in turmeric provide an anti-inflammatory effect that may provide modest benefit in rheumatoid arthritis and osteoarthritis, although no better than anti-inflammatory medicines

Long-term use of metformin (for type 2 diabetes) or proton pump inhibitors can also deplete B12 levels over time

Smaller, more metabolically active fat cells, higher energy, and improved body composition