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As they also demonstrated that PKC mediated morphine-induced MOR desensitization, it can be inferred that PKC would phosphorylate MOR at other sites than S363, T370, and S375

Consider a drug with a high extraction ratio of E = 0.9, resulting in an oral bioavailability of F = 10% (1 - 0.9)

While Dihexa itself is not yet approved for widespread medical treatments, it is accessible through research libraries and specialized peptide vendors

Figure 1 D1-like DRs are coupled to the stimulatory G-subunit, Gs, whereas D2-like DRs, are coupled to the inhibitory G-subunit, Gi

Urban et al., 2004)

Because AOD 9604 does not significantly alter hormone levels, it avoids many side effects linked to HGH, such as joint pain or insulin resistance