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Penelitian telah menunjukkan bahwa orang dengan penyakit ini sering kali memiliki tingkat glutathione yang lebih rendah di otaknya

PMID 22217824

Ser/gly synthesis dependence led to an enhanced synthesis of nucleotides in 2012.2 GBM cells, as well as in 1919 GBM isogenic models with overexpression of PSPH and the PSPH V116I mutation, which explains their high sensitivity to the inhibitory effects of sertraline plus chloroquine treatment