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Specifically, one study found that when leaky Madin-Darby canine kidney type II cells were treated with LA, tight junction proteins, including occludin and claudin-3, had less intracellular distribution (and concurrently more membrane expression), whereas actin was more associated with intercellular junctions (25)

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However, unlike in the liver, the primary enzyme responsible for the first oxidative step from ethanol to acetaldehyde in the brain is catalase, accounting for approximately 60% of ethanol metabolism (at least in rodents)

Endocr Rev 39(5):760802 Zhang H et al (2021) PPARalpha agonist relieves spinal cord injury in rats by activating Nrf2/HO-1 via the Raf-1/MEK/ERK pathway

PMID: 28068788