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10.1038/nsmb1222 154 SarutipaiboonI.SettasatianN.KomanasinN.KukongwiriyapanU.SawanyawisuthK.IntharaphetP.et al

All observations from preclinical (swine) models

Pathophysiology of MSL Hypothesis 1: Brown Adipose Tissue The dorsocervical fat pad (buffalo hump) is thought to be a location of brown adipose tissue found both in MSL (264,269,270) and HIV-associated lipodystrophy (271-274) suggesting that the abnormal fat tissue in both of these conditions arises from brown adipocytes (275)