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The answer, put simply, is cellular senescence: FOXO4 can interact with p53, which is involved in the regulation of multiple target genes and controls a wide range of cellular processes, including metabolic adaptation, DNA repair, cell cycle arrest, apoptosis, and senescence

Xi bao yu fen zi mian yi xue za zhi = Chin J Cell Mol Immunol (2020) 36(6):53541

1992 May 15;89(10):4678-82

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