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thaliana , overexpressed NRAMP6 resulted in Cd hypersensitivity through increased Cd uptake, while nramp6 loss of function mutants resulted in reduced Cd uptake leading to increased plant tolerance when exposed to high levels of Cd ( NRAMP5 resulted in reduced Cd accumulation in roots and leaves (Sasaki et al., 2012)

doi: 10.1002/ajh.24088 25 GrayL

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Mouse intestinal epithelial organoids Intestinal epithelial organoids were cultured from 4- to 8-week-old Gpx4 +/IEC and littermate WT mice using IntestiCult Organoid Growth Medium (Stemcell Technologies, 06005) and a protocol adapted from manufacturers instructions as initially described 58

In melanoma cells, curcumin can cause time and dose-dependent apoptosis that is not dependent on p53 activation