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Although mTORC1 activation hinders autophagy, evidence has shown that autophagy can be upregulated in tumors with mTORC1 hyperactivation 168

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Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 inhibition in liver cancer

An illustrative non-limiting substitution in a position corresponding to one or more of positions 273, 276, 306 , 326, 332, 338, 420 and / or 424 is an acidic or neutral amino acid residue, such as Asp (D), Glu (E), Ala (A), Gly (G), Ser (S), Cys (C), Asn (N), Gln (Q), Ile (I), Leu (L), Met (M), Phe (F), Pro (P), Thr (T), Trp (W), Tyr (Y) or Val (V), for example substitutions by A or E

Moreover, we found that elevated expression of NRG1 in KRAS G13D cells further promotes HER2HER3 interaction, reinforcing this signaling axis (Supplementary Figs

These strategies, rooted in a deep understanding of ferroptosis biology, hold the potential to revolutionize the management of COPD by moving beyond symptomatic control to directly targeting a core cell death mechanism