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4 Conclusion Mitochondria orchestrate radioresistance through interconnected mechanisms: metabolic reprogramming (enhanced OXPHOS, glycolysis, and PPP flux), ROS regulation (upregulated antioxidant enzymes, GSH, NRF2), dynamic remodeling (Drp1mediated fission, OPA1/Mfn fusion), apoptotic dysregulation (Bcl2 family overexpression, IAPmediated caspase blockade), and mtDNA repair (Pol , SSBP1, EXOG)