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Additionally, icaritin demonstrates pro-apoptotic effects in extranodal NK/T-cell lymphoma (SNT-8 and SNT-10), cervical cancer (Hela), liver cancer (Hep G2) cells and neuroblastoma (TDP-43-transfected SH-SY5Y) cells [735, 736, 742,743,744]

Compounded medications are personalised formulations, designed to meet individual patient needs when commercially available medicines are unsuitable

This suggests that low levels may make symptoms worse compared with adequate vitamin D levels

Targeting the prolineglutamineasparaginearginine metabolic axis in amino acid starvation cancer therapy

They also promote macrophages to polarize into the M1 phenotype and stimulate a positive feedback loop, increasing cytokine production and killing more islets (8)

10.1186/s12951-021-01195-7 413 ZhangK.ZhaoX.ChenX.WeiY.DuW.WangY.et al (2018)