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Alternatively, urinary excretion of 6-sulfatoxymelatonin is a good index of nocturnal melatonin production and it should be collected as sequential urine samples for 48h in order to calculate the timing of the peak or acrophase

Individuals with gastrointestinal disorders- Conditions such as Crohns disease, coeliac disease, and pernicious anaemia can all impair the absorption of b12, and stomach and bowel surgeries can also limit absorption

In a healthy body, B12 ensures that melanin is produced and distributed evenly

Synaptic signal recording Considering the gene mutations related to synaptic structure or function that have been observed in epileptic patients (Lammertse et al., 2020), alterations in synaptic connections and transmission should be considered when investigating the underlying mechanisms of epileptic candidate genes

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