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As part of the innate immune response, complement system dysregulation is implicated in AMD pathogenesis, with zinc able to bind CFH and other complement proteins to modulate inflammatory responses [437, 438]

The trade-off is increased complexity, cost, two separate injections, and additional side effect management

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Affinity chromatography Aarya B

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Inhibition of the proteasome by MG132 followed by affinity enrichment of ubiquitinated proteins with the UbiQapture-Q matrix resulted in 1.6-fold more bona fide poly-ubiquitinated proteins captured in NatA depleted plants when compared to wild type as detected with a ubiquitin-specific antiserum (Fig