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Following the study, it was reported that weight appeared to be reduced in all rats by over 50%, in comparison to the rats given a placebo

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Clinical evaluation included daily assessment of lameness, defined as the inability of the rabbit to bear weight and maintain the typical flexion-extension cycle of the affected limb compared to the unaffected limb

Bleomycin-induced mouse fibrosis model and administration of anti-CD38 antibodies All animal studies were conducted in accordance with NIH guidelines for the care and use of laboratory animals and animal protocols were institutionally approved by the Animal Care and Use Committees of Northwestern University and the University of Michigan