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ROS-induced oxidation of PUFAs results in peroxidation of lipids, whose breakdown products, such as 4-hydroxy-2-nonenal (4-HNE), act as signaling molecules triggering inflammation, ferroptosis, inflammation, or other processes

Antioxidant enzyme activity assay For the enzyme assays, 0.3 g of leaf sample was ground in 3 mL of ice-cold 25 mM HEPES buffer (pH 7.8) containing 0.2 mM EDTA, 2 mM AsA, and 2% PVP

CAPE and its synthetic derivative VP961 restore BACH1/NRF2 axis in Down syndrome

LION -formulated repRNA offers significant advantages over other RNA vaccine platforms, including limiting the dissemination of RNA to the injection site which induces antigen-specific adaptive immunity while avoiding systemic inflammation 37

2015 Oct 23;16(10):2523463

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