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Carriers of the UGT1A4*3 variant can experience reduced therapeutic efficacy due to ultrarapid glucuronidation, thus higher doses of some UGT1A4 substrates may be required for people carrying the UGT1A4*3 variant, such as seen during posaconazole treatment as an antifungal prophylaxis during treatment of hematological malignancies

Zhang, C., Vinogradova, E

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ATP contents and the mitochondrial complex I activity Cell lysates from the described treatments were analyzed using an ATP assay kit and a mitochondrial complex I activity kit (both from Biyuntian, Wuxi, China)