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Even though daily injections of sermorelin are capable of shutting GHRH production in neurons and synthesis of GHRH receptors in brain and pituitary, these effects are fully manifest after a period of time

Like any treatment, CJC-1295 and Ipamorelin can have side effects

It's incredibly selective

[5] As a treatment, once-daily subcutaneous sermorelin (about 30 g/kg at bedtime) increased height velocity in some prepubertal children with idiopathic growth-hormone deficiency, with responses sustained over roughly 12 months and, in a few children, longer

The short answer is: very rarely, and to a dramatically lesser extent than other GHRPs

Unmanaged stress, which can affect cortisol levels, sleep, appetite, recovery, and hormone signaling