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Establishment of protocols for global metabolomics by LC-MS for biomarker discovery

The most common pathogen affecting the airways in CF patients is Pseudomonas Aeruginosa (PA), although other microorganisms may play an important role on the pathogenesis of lung function declines, such as Haemophilius influenzae, Staphilococcus aureus, Stenotrophomonas maltophilia, Burkholderia cepacian (Rowe et al., 2005

A prospective observational trial

Additionally, arsenic activates caspase-3 and caspase-9, leading to apoptosis (Sinha et al., 2013

Indeed, in 23 patients out of a total of 25, 5-MTHF in CSF was low despite normal serum folate treatment with folinic acid for a year restored folate levels and led to clinical improvements