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It was suggested that melatonin administration in chondrocytes increased the upregulation of key chondrogenic marker genes, including Sox9, aggrecan, and collagen II via the TGF-1 signaling pathway (171)

53, 9991012.10.1111/j.1365-313X.2007.03389.x 52 PolekhinaG.BoardP

doi: 10.1038/nature15514 65 KayagakiNStoweIBLeeBLO'RourkeKAndersonKWarmingSet al

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