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Prolonged stimulation of exhausted lymphocytes, which demonstrate attenuated effector function and cytokine secretion in nutrient-depleted microenvironments, by antigen presenting cells via HLA class 1 leads to increased cellular exhaustion 88 , which further impairs the capacity of cells to differentiate into memory phenotypes

However, type I interferon pathway was strongly activated in B16-F10 when we used specific agonists to TLR3 (Poly I:C) or cGAS-STING (dsDNA90) ( Figures 2G, H )

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Research in this field is rapidly producing advancements, with new epigenetic mechanisms in ferroptosis being uncovered at an ever-increasing rate

doi: 10.1186/1476-4598-9-135 95 OlivierCOliverLLalierLValletteFM

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