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The P-loop stabilizes the phosphate groups of the bound nucleotides, while the Switch regions form critical interfaces for interacting with effector proteins and regulatory molecules, including GTPase-activating proteins (GAPs) and GTP exchange factors (GEFs) [15]

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Iran J Public Health

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Still, the gene KLF10 which is a transcriptional repressor was significantly downregulated at both 0.1 M and 1 M, suggesting that some expression changes may occur at lower doses of Al-CPI