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Description

At the cellular interface, dermal fibroblasts regulate spreading, migration, and extracellular matrix (ECM) turnover through integrin-dependent adhesion signaling (e.g., FAK/ERK pathways), which is central to fibroblastECM homeostasis [48]

230 ZhaoM

By incorporating cells that retain the molecular and functional features of the native tissue, these platforms allow researchers to reproduce patient specific disease mechanisms and treatment responses in vitro