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Animals treated with CBD showed reduced nigrostriatal degeneration and neuroinflammatory response together with improved motor performance

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Among the most studied agents for this purpose is Erastin, a compound that induces ferroptosis through a distinct mechanism

For instance, VLX-600 dually targets iron and OXPHOS to promote autophagy-mediated cell death in glioblastoma cells, suggesting an interesting novel strategy to combat high OXPHOS cancer cells [101]

Despite promising Phase 2 results and an excellent safety profile, the compound could not demonstrate sufficient efficacy in the larger confirmatory trial to justify the investment required for continued pharmaceutical development toward regulatory approval

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