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Description

Tumors have evolved a unique microenvironment, and typically display a more acidic condition, hypoxia, overexpressed reactive oxygen species (ROS), and glutathione (GSH) owing to their rapid proliferation and metabolism (Mura et al., 2013

Both PGRN and granulins are thought to play a critical role in lysosomal function [95, 96], although the exact functions of individual granulins versus PGRN remain unclear