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The authors suggest that esterase-mediated cleavage of the ester bond in the conjugate could liberate the kinase-inhibitor in a slow-release process, increasing the bioavailability of dasatinib in the tumor parenchyma, but direct evidence is lacking (122)

This can be incredibly useful for protocols that require smaller or more micro-dosed measurements, as it makes measuring those tiny amounts easier and more accurate

As TCM metabolites move into mainstream use, physicians will need clear information on any contraindications or interactions with conventional drugs

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Therefore, in CHI there is the absence of both glucose and ketones as primary and alternative fuel sources for brain cells, leading to brain damage