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Studies using IL-23-induced mouse models of psoriasis show that the targeted deletion of EP2 and EP4 receptors on T cells results in the suppression of Th17 cell accumulation and associated cutaneous inflammation (55)

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FIGURE 5 2.2.10.1 In vitro Cellular Studies Regarding its antifibrotic potential, cell culture experiments on human lung fibroblasts and alveolar epithelial cells have revealed that PFD is able to inhibit fibroblast proliferation, myofibroblast differentiation, collagen synthesis, fibronectin production, deposition of ECM components, and -SMA and HSP47 expression (Nakayama et al., 2008