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Despite the use of TMZ for the treatment of GMB has shown some advantages, such as moderate side effects and increased life expectancy in patients, GBM frequently develops primary and secondary resistance to this drug due to the overexpression of O6-methylguanine-DNA-methyltransferase (MGMT) protein, which can repair the DNA damage induced by TMZ, thus preventing apoptosis of cancer cells and favoring tumor recurrence [15]

Thiopurines are also commonly used as adjunct therapy in a step-down strategy for treating severe CD

The smell, however, is quite strong, so we ultimately cut it from the list

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doi: 10.1002/ptr.70018 38

It should involve a qualified dermatologist from the first consultation