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Traditional necrosis, characterized by organelle disintegration, oncosis, degeneration of proteins and enzymes in vivo , and plasma membrane rupture (15), evokes inflammatory responses by releasing damage-associated molecular patterns (DAMP) that trigger an immune response known as necroinflammation (16)

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Total, free, and esterified carnitine levels should be determined

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Expanding on the concept of clinical chemistry towards clinical metabolomics, monitoring metabolism at scale in large populations (e.g., millions of blood donors) may thus provide insights into population health as a complementary tool to genetic screening and standard clinical measurements.