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Due to this, in most phase 2 trials of combination therapy against HBV, including siRNA or ASO with pharmacological HBV inhibitors (nucleos(t)ide analogues, CpAM, TLR7 agonist, and PEG-IFN), large proportion of patients experienced viral relapse after therapy

(5), were part of the household

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This is achieved through surface modifications with targeting ligands, such as antibodies or peptides, enhancing their ability to be taken up by cells and localized precisely at the site of the disease

Peptides are typically administered via subcutaneous injection, but some are available as oral capsules, troches, or nasal sprays