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145 Perturbations in this quality-control mechanism exacerbate hyperlipidemia and hepatic steatosis, further illustrating how ERAD links intracellular proteostasis to circulating lipid levels and cardiometabolic risk

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Category 2 substances also have sufficient supporting information, but the FDA has identified significant safety risks

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Overall, fuel cannot be metabolized and converted into energy without NAD + [9, 10]