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Distinct signatures of gut microbiome and metabolites associated with significant fibrosis in non-obese NAFLD

In particular, proton pump inhibitors (PPIs, a class of drugs used to treat gastroesophageal reflux and peptic ulcer) may contribute to the progression of eosinophilic esophagitis by hindering the digestion of food allergens, contributing to impaired gut barrier function that leads to the absorption of undigested food allergens, and causing microbiome imbalance

10.1016/j.bios.2020.112733 375 WuY.GuS.CobbJ

Persistent senescent cells have been associated with aging or age-related diseases via secretion of proinflammatory cytokines that alter the tissue microenvironment or modify the function of normal cells (Baker et al., 2011)

Moreover, Petty et al., observed that neutrophils under high glucose stimulation mainly use the PPP for ROS generation, with the inhibition of PPP or NOX attenuating high glucose-induced ROS generation in neutrophils (Petty et al., 2005) (Table 3)

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