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J Pharmacol Exp Ther 322(1):378384

The therapeutic efficacy of SP@M was further quantitatively evaluated using a clinically tested scoring system

Used as a research tool to study fat-cell signalling without glucose effects

t-Darpp activates IGF-1R signaling to regulate glucose metabolism in trastuzumab-resistant breast cancer cells

There was even a theory originally put out in the 1950s called The Free Radical Theory of Aging* which basically held that we age by rusting from within, due largely (but not exclusively) to free radical damage