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This enzymatic degradation occurs so quickly that when L-Carnosine is applied topically to the eye, studies have shown it fails to accumulate in the aqueous humor in meaningful concentrations compared to placebo treatments

doi:10.15620/cdc:122556

Parallel to the DAF-2/DAF-16 pathway, the c-Jun N-terminal kinase (JNK) pathway is activated by environmental stresses and inflammatory cytokines and acts as a molecular sensor for the pathway DAF-2/DAF-16 (139)