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Flavonoid mixture (diosmin, troxerutin, rutin, hesperidin, quercetin) in the treatment of I-III degree hemorroidal disease: a double-blind multicenter prospective comparative study

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Herein, we present the functionalisation of TIPS microparticles with both small molecules and an antibody fragment of Herceptin, via a heterobifunctional pyridazinedione linker capable of participating in SPAAC click chemistry, and compare it to the traditional method of preparing active-targeted microparticle systems, that is, physisorption of antibodies to the microparticle surface

Fox and Nobile, 2012)