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however, we believe that this effect is more likely indirectly caused by PPI-induced cholelithiasis and biliary tract infections

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Results: 1) Study in CLD: No of non-SP/NI-SP/I-SP patients was 519/164/53, and the incidence of patients with HCC was significantly higher in I-SP at 2%, 4%, and 28% (p 0.01), with a predictive value of -2.42 for I-SP (AUC: 0.95, p 250 on paracentesis during admission

Nature 432 , 622625 (2004)