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As a scavenger of toxic free radicals, GSNO is 100-fold more potent in neutralizing ROS than GSH and is further metabolized by an evolutionary conserved enzyme S-nitrosoglutathione reductase (GSNOR) at the expense of NADH to generate GSSG and ammonia (Figure 3)

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Additionally, the reduction in CoA levels and the GSH/GSSG ratio following erastin treatment in NINJ1-overexpressing cells were reversed by xCT restoration (Fig