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Crocin Exerts Anti-Inflammatory and Anti-Arthritic Effects on Type II Collagen-Induced Arthritis in Rats

Liquid chromatography coupled to mass spectrometry (LCMS) HILIC chromatographic separation of metabolites was achieved using a Millipore Sequant ZIC-pHILIC analytical column (5 m, 2.1 150 mm 2 ) equipped with a 2.1 20 mm 2 guard column (both 5 mm particle size) with a binary solvent system

6 Argueta-DonohuJ.CarrilloN.Valds-ReyesL.ZentellaA.Aguirre-GarcaM.BeckerI.et al (2008)

Statistical significance between pairs of groups was assessed using an unpaired two-sided t-test, one-way ANOVA followed by the Dunnett multiple comparison test, or two-way ANOVA with the Tukey multiple comparison test, as indicated

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As suggested, vitamin D3 elevates microglial IL-10 expression