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Accessed July 19, 2022

Neurotrophins promote neural survival while substantial decreases in their levels have been measure in several neurodegenerative diseases

Four components of the COP9 signalosome complex (CSN)a deNEDDylase that regulates the ubiquitination activity of cullin-RING E3 ligases and modulates various targets in inflammation 46 were identified as exosome-mediated, itaconated secreted proteins (Fig