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It's garnered significant attention for its role as an NNMT inhibitor, a mechanism we'll get into shortly

And ensure that serotonin is produced in the brain instead

10.1007/s10637-012-9841-7 27 HuY.LiuJ.CuiP.LiuT.PiaoC.XuX.et al (2020)

In macrophages and monocytes, lactate binds to GPR81 and reduces the effects induced by TLR4 agonists such as NF-B activation, the release of IL-1, and cleavage of CASP1, via ARRB2 (115) ( Table 1 )